講師：Dr. Uwe Schneider
所属：The University of Edinburgh, UK
題目：Catalytic C–C Bond Formations Facilitated by Novel Catalyst Systems
講演要旨：Based on our earlier studies on ambiphilic low-oxidation gallium catalysis, we have recently developed the first catalysis by a carbodiphosphorane, i.e., a dibasic low-oxidation carbon species. In contrast to strong metal–bases and other organobases, this carbon(0) compound was found to efficiently activate aliphatic nitriles and/or α,β-unsaturated amides in view of catalytic conjugate cyanoalkylation of these Michael acceptors. Similarly, following on our recent sodium–amide catalysis, we have uncovered an unusual C2–H bond activation of N-unprotected indoles catalyzed by a heterobimetallic carbonate. The seminar will focus on the catalytic (formal) C–H bond activations in the absence of precious metals; including discovery & development, scope, as well as insight into the mechanism.